Abstract

Conventional antimicrobials become increasingly ineffective against multidrug resistant pathogens. Nowadays, the search for new bioactive molecules is of paramount importance. Pyrazoles are a new class of bioactive molecules that can enhance the therapeutic arsenal in the coming years. Fifteen compounds based on pyrazole and primary amines were tested in vitro against one fungal strain, namely Fusarium oxysporum f.sp.albedinis and three bacterial strains, namely Bacillus subtilis, Micrococcus luteus and Escherichia coli. The results showed that some compounds containing (-OH) group and phenyl moiety have a considerable effect against tested bacteria and some compounds containing the (-Br) group have higher activity against tested fungus. The obtained results prove that pyrazolic compounds have an antimicrobial potential and inspired us to conduct more researches in order to use them in therapeutics.